SkyEater OO Pro is a monophonic synthesizer for OS X.
You can play melody with keyboard of your mac.
In Pro version, you can edit parameters for the sound engine. (Oscillator types, Attack time, Release time, Glide value, Echo, Tremolo, Reverb and master volume)
Demonstration:
http://www.youtube.com/watch?v=qqIH8lt6zQs
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